I can't guarantee it will work without FOSE, or if not having FOSE installed will ensure problems in future saves. No worries, this save is set to only rely on Fallout3.esm so you don't have to be annoyed about any missing mods to run this savegame other than FOSE. This is a save game of my Anita character for those that do not want to use the vanilla Hispanic race or the unique race. Just a simple addition to the vanilla preset. I created it for those that do not want to use her as a save or unique race.
Which means Anita shares the same meshes and textures as all 4 vanilla female races. This preset is included with the vanilla Hispanic presets. No worries, I've created a unique child race to bypass the tranquility Lane to link with this Anita's unique race so when you finish the mini quest you return to being Anita and not a different looking character. You can add what ever face/body/hand mesh and texture you wish and it won't effect the rest of the female characters in game.
I've created Anita as a unique race/preset here. I suggest reading the readme provided for each archive to know more info. Anita Preset - Unique Race, Vanilla Hispanic Race & Savegame